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Phototherapy is the main treatment of neonatal jaundice. Babies with neonatal jaundice may be treated with colored light called phototherapy, which works by changing trans-bilirubin into the water-soluble cis-bilirubin isomer. [26] [27] [28]: 2533
Jaundice in some babies can disappear within one to two weeks without treatment; however for babies with more severe jaundice, treatment is required. Traditional phototherapy devices include blue LEDs, halogen white light, and fluorescent tubes. A biliblanket is a phototherapy home treatment that consists of a portable illuminator and fiber ...
Most children will also require a liver transplant in the future because they will progress to having cirrhosis, hepatocellular carcinoma, and/or chronic liver disease. [13] Generally, treatment of neonatal cholestasis involves treating the underlying disease. Prognosis of neonatal cholestasis also varies based on the underlying pathologic process.
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Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. [3] [6] Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. [7]
As high biliverdin levels are usually related to bilirubinemia, tin mesoporphyrin has been found to aid in treatment and prevention of this, primarily in newborn infants. Tin mesoporphyrin competitively inhibits the heme oxygenase enzyme, which prevents the breakdown of heme to biliverdin leading to accumulation of heme and not bilirubin. [6]
The app could help identify severe cases in low and middle-income countries to prevent complications.
Jaundice occurs when blood contains an excess amount of bilirubin. “For most babies this is not a big deal, it clears out,” Tiffany Green, an associate professor in the obstetrics and ...