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Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins , endogenous signaling molecules known to cause these symptoms.
Hemicrania continua generally responds only to indomethacin 25–300 mg daily, which must be continued long term. Unfortunately, gastrointestinal side effects are a common problem with indomethacin, which may require additional acid-suppression therapy to control. [10]
CPH headaches are treated through the use of non-steroidal anti-inflammatory drugs, with indomethacin found to be especially effective in eliminating symptoms. Paroxysmal hemicrania is classified by the characteristic (high) frequency and (short) duration of attacks experienced by patients that is somewhat similar to cluster headaches , despite ...
The chronic use of NSAIDs inhibit the synthesis of prostaglandins and thromboxanes, which leads to renal vasoconstriction. [18] This results in a decreased blood flow to the kidneys. [18] Therefore, patients taking NSAIDs in long term are in higher risk of developing chronic renal diseases and nephrotoxicity due to reduced renal perfusion.
Use as a tocolytic agent may result in death of the fetus or infant. [40] Flushing, lethargy, headache, muscle weakness, diplopia, dry mouth, pulmonary edema, cardiac arrest [42] Lethargy, hypotonia, respiratory depression, demineralization with prolonged use [42] Ethanol: GABA A receptor PAM: Shown to be ineffective: no better than placebo. [22]
Bronchorrhea is the production of more than 100 mL per day of watery sputum. [1] Chronic bronchitis is a common cause, but it may also be caused by asthma, [2] pulmonary contusion, [3] bronchiectasis, tuberculosis, cancer, scorpion stings, severe hypothermia and poisoning by organophosphates and other poisons.
More research is needed on Ozempic long-term side effects. Some severe side effects with long-term consequences may include pancreatitis, acute kidney injury, gallstones, gallbladder disease ...
It may be less nephrotoxic than indomethacin. [7] There are two known polymorphs of the compound. [8] Nabumetone has little effect on renal prostaglandin secretion and less of an association with heart failure than other traditional drugs of the class. [9]