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Micrograph of a basal-cell carcinoma, showing the characteristic histomorphologic features (peripheral palisading, myxoid stroma, artefactual clefting). H&E stain. Basal-cell carcinoma is named after the basal cells that populate the lowest layer of the epidermis due to the histological appearance of the cancer cells under the microscope. [16]
In the case of Bas-SqCC, it is essential that both evidence of squamous differentiation (i.e., intercellular bridges, production of keratin, tonofilament bundles) and basaloid architecture (i.e. prominent peripheral palisading of cell nuclei, organoid/lobular structures) are identified to make a correct diagnosis. [3] [7]
Tumor lobules were arranged as monomorphous basaloid cells in a cribriform pattern with peripheral palisading some resembling abortive hair follicles (B, F). Focally, tumor lobules exhibited squamous eddies, papillary mesenchymal bodies, and a germinative component comprising basaloid cells admixed with distinct pales cells (Zellballen) (C–E ...
Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. [11] They were first recognized as distinct clinicopathological variants of both squamous cell and large cell lung cancers in 1999, within the third revision of the World Health Organization lung tumor typing and classification scheme.
Micrograph of an ameloblastoma showing characteristic palisading. H&E stain. In histopathology, a palisade is a single layer of relatively long cells, arranged loosely perpendicular to a surface and parallel to each other. [1] A rosette is a palisade in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. [2]
Favorable pattern: partially encapsulated with bland basaloid cells and intervening stroma. Unfavorable pattern: Infiltrating borders with perineural or perivascular invasion. Both patterns have basaloid cells arranged in solid nests, nodules or trabecula, with focal peripheral palisading.
Scientists have characterized the role of thousands of mutations in the BRCA2 cancer gene, findings that may help reassure worried patients about their cancer risk or guide doctors toward better ...
Trichoepitheliomas consists of nests of basaloid cells, with palisading. They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal cell carcinoma.