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Furthermore, recent studies show that intrapleural tissue plasminogen activator (tPA), a protein that is responsible for the breakdown of blood clots, combined with deoxyribonuclease increase pleural drainage, decreases hospital length of stay, and decreases the need for surgery in parapneumonic effusions and empyema.
Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. [5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides.
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Biomedicine is the cornerstone of modern health care and laboratory diagnostics.It concerns a wide range of scientific and technological approaches: from in vitro diagnostics [7] [8] to in vitro fertilisation, [9] from the molecular mechanisms of cystic fibrosis to the population dynamics of the HIV virus, from the understanding of molecular interactions to the study of carcinogenesis, [10 ...
Biomolecules and Biomedicine is a bimonthly peer-reviewed open-access medical journal published by the Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina. The journal covers research across the spectrum of pre-clinical studies, translational medicine, and clinical research. [ 1 ]
Some regulatory agencies use the terms biological medicinal products or therapeutic biological product to refer specifically to engineered macromolecular products like protein- and nucleic acid-based drugs, distinguishing them from products like blood, blood components, or vaccines, which are usually extracted directly from a biological source.
11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone (), deoxycortone, and cortexone, [1] [2] is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. [3]
Typically, the body stops making fetal hemoglobin around 6 months of age, and starts making adult hemoglobin. [10] These serve similar functions, however fetal hemoglobin has a higher binding affinity for oxygen than adult hemoglobin, but both are functional at transporting oxygen in the body. [10]