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6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .
5-MeO-DMT is lipophilic and is thought to easily cross the blood–brain barrier. [2] Accordingly, 5-MeO-DMT readily accumulates in the brain in animals with levels higher than in blood. [2] This is in notable contrast to bufotenin (5-HO-DMT or N,N-dimethylserotonin) and serotonin (5-HT), which are hydrophilic and peripherally selective. [2 ...
DMT is commonly handled and stored as a hemifumarate, [92] [93] as other DMT acid salts are extremely hygroscopic and will not readily crystallize. Its freebase form, although less stable than DMT hemifumarate, is favored by recreational users choosing to vaporize the chemical as it has a lower boiling point. [92]
Several 5-HT 2A agonist hallucinogens including (R)-2,5-dimethoxy-4-iodoamphetamine DOI, TCB-2, LSD and LA-SS-Az have unexpectedly also been found to act as potent inhibitors of TNF, with DOI being the most active, showing TNF inhibition in the picomolar range, an order of magnitude more potent than its action as a hallucinogen.
2,5-Dimethoxy-4-methylamphetamine (DOM; known as STP, standing for "Serenity, Tranquility and Peace") is a psychedelic and a substituted amphetamine.It was first synthesized by Alexander Shulgin, and later reported in his book PiHKAL: A Chemical Love Story.
As with DMT, CYB004 is a potent agonist of the serotonin 5-HT 2A receptor and produces psychedelic-like effects in animals. [ 1 ] [ 5 ] [ 3 ] However, CYB004, due to its deuteration, is more resistant to metabolism than DMT and shows a longer elimination half-life (by 2.5- to 2.9-fold) and slower clearance (by 38 to 55%) in animals. [ 3 ]
Dimethyltryptamine-N-oxide (DMT-N-oxide) is a dimethyltryptamine metabolite. [1] References This page was last edited on 15 April 2021, at 12:10 (UTC). Text is ...
Psilocin, also known as 4-hydroxy-N,N-dimethyltryptamine (4-OH-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms [ 7 ] together with its phosphorylated counterpart psilocybin .