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GLP-1 agonists are a class of medications that mimic the action of the hormone GLP-1 (glucagon-like peptide-1), which is involved in insulin production and appetite regulation. “GLP-1 stands for ...
Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon peptide. It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption.
Aleniglipron (development code GSBR-1290) is a small-molecule GLP-1 agonist developed by Structure Therapeutics. [1] It is delivered orally and is in a Phase II trial as of 2023.
Attempts to develop an orally bioavailable GLP-1 agonist, either a modified peptide, as in the case of oral semaglutide, [37] or a small molecule drug, have produced additional drug candidates. [28] Other companies have tested inhaled or transdermal administration.
The use of glucagon-like peptide-1 receptor agonists (GLP-1 agonists) for weight loss has been greatly increasing. Past studies show there are positive and negative side effects from GLP-1 ...
A new study in mice suggests that blocking the GLP-1 receptor may help defend against colorectal cancer, begging the question: Do drugs like Wegovy and Zepbound have ill effects in cancer?