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Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
Vitamin B 12 was discovered as a result of pernicious anemia, an autoimmune disorder in which the blood has a lower than normal number of red blood cells, due to a deficiency of vitamin B 12. [5] [16] The ability to absorb the vitamin declines with age, especially in people over 60. [17]
TC-2 binds cobalamin once it has been taken up by enterocytes of the terminal ileum and the "Intrinsic Factor-Vitamin B12" complex has been degraded. TC-2 is then involved with the transport of Vitamin B12 to the tissues, where it binds to its plasma membrane receptor (TC-2R), a heavily glycosylated protein with a monomeric molecular mass of 62 ...
“Vitamin B12 is necessary for normal processing of carbs, proteins, and fats in the body and for the normal formation of red blood cells,” adds Elizabeth Somer, M.S., R.D.N., a dietitian based ...
Blood tests may show low levels of vitamin B 12, elevated levels of methylmalonic acid or homocysteine, and a routine complete blood counts may shows anemia with an elevated mean cell volume. [140] The presence of antibodies to gastric parietal cells and intrinsic factor may indicate pernicious anemia. [2]
2. Vitamin B12. One of eight B-complex vitamins, vitamin B12 is found naturally in some types of fish, red meat and fortified foods.It plays a key role in central nervous system function, DNA ...
When suspected, diagnosis is made by blood tests initially a complete blood count, and occasionally, bone marrow tests. [6] Blood tests may show fewer but larger red blood cells, low numbers of young red blood cells, low levels of vitamin B 12, and antibodies to intrinsic factor. [6] Diagnosis is not always straightforward and can be ...
In the breakdown of my blood-based biomarkers, I was pleased to see my biological age is two years younger than my chronological age. But, I wanted to learn more about my overall Lifescore of 70 ...