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Ball-and-stick model of cimetidine, the prototypical H 2 receptor antagonist. H 2 antagonists, sometimes referred to as H2RAs [1] and also called H 2 blockers, are a class of medications that block the action of histamine at the histamine H 2 receptors of the parietal cells in the stomach.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia , although they have been surpassed in popularity by the more effective [ 1 ] proton pump inhibitors .
Starting Jan. 1, older adults on Medicare will spend no more than $2,000 a year on prescription drugs when a new price cap on out-of-pocket payments from the Inflation Reduction Act goes into effect.
The negotiated drug prices would have to meet the following criteria: The negotiated drug price does not exceed than 120% of the drug's average price in Canada, the United Kingdom, Australia, Germany, France, and Japan. If that data is not available, then the price must not exceed 85% of the United States average manufacturer price.
It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year. [ 8 ] [ 10 ] In 2022, it was the 46th most commonly prescribed medication in the United States, with more than 13 million prescriptions.
Prescription drug list prices in the United States continually are among the highest in the world. [1] [2] The high cost of prescription drugs became a major topic of discussion in the 21st century, leading up to the American health care reform debate of 2009, and received renewed attention in 2015.