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Vitamin B 12 deficiency can be determined, but not always. [14] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [151] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
One of the superpowers of vitamin B12 is that it is the only water-soluble vitamin that can be stored in the human body, Kitchens points out, and it can remain stored in the liver for several years.
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
[6] [15] [26] Vitamin B 12 deficiency can also cause symptoms of mania and psychosis. [27] [28] Among other problems, weakened immunity, reduced fertility and interruption of blood circulation in women may occur. [29] The main type of vitamin B12 deficiency anemia is pernicious anemia, [30] characterized by a triad of symptoms:
D. latum causes B12 deficiency in humans [11] leading to megaloblastic or pernicious anemia. [ 12 ] [ 13 ] The worm absorbs around 80% of dietary B12 and prolonged infection can also cause abdominal pain, mechanical obstruction, and symptoms of iron deficiency anemia. [ 14 ]
The vitamin B12 was recently linked with dementia in a new study. Doctors explain how much you should be getting, and the major signs that your levels are off.
A 2023 review found that substituting animal-source with plant-based foods is associated with a lower risk of cardiovascular disease and all-cause mortality. [16] A 2024 review found that plant-based meat alternatives have the potential to be healthier than animal-source foods and have smaller environmental footprints.
Deficiency can also result from rare genetic factors, such as mutations in the MTHFR gene that lead to compromised folate metabolism. [33] [34] Cerebral folate deficiency is a rare condition in which concentrations of folate are low in the brain despite being normal in the blood. [35] Vitamin B 12 deficiency: Anemia, neurological and digestive ...