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  2. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    The average cell will divide between 50 and 70 times before cell death. As the cell divides the telomeres on the end of the chromosome get smaller. The Hayflick limit is the theoretical limit to the number of times a cell may divide until the telomere becomes so short that division is inhibited and the cell enters senescence.

  3. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    When the cell does this due to telomere-shortening, the ends of different chromosomes can be attached to each other. This solves the problem of lacking telomeres, but during cell division anaphase, the fused chromosomes are randomly ripped apart, causing many mutations and chromosomal abnormalities. As this process continues, the cell's genome ...

  4. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    Almost all cancer cells have shortened telomeres. [20] This may seem counter-intuitive, as short telomeres should activate the ATR/ATM DNA damage checkpoint and thereby prevent division. Resolving the question of why cancer cells have short telomeres led to the development of a two-stage model for how cancer cells subvert telomeric regulation ...

  5. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    Telomere length is different in different tissues and cell types of the body. [10] Developing a general telomere lengthening strategy that is effective in all tissues is a complex task; Also, understanding how different types of cells, organs and systems react to telomere manipulation is very important for developing safe and effective ...

  6. Cellular senescence - Wikipedia

    en.wikipedia.org/wiki/Cellular_senescence

    The Hayflick limit deliberates that the average cell will divide around 50 times before reaching a stage known as senescence. As the cell divides, the telomeres on the end of a linear chromosome get shorter. The telomeres will eventually no longer be present on the chromosome.

  7. How Inflammation Ages You—Plus 4 Ways to Reduce ... - AOL

    www.aol.com/lifestyle/inflammation-ages-plus-4...

    If telomeres become too short, cells may not be able to divide or work properly anymore, which may accelerate aging. It Decreases Your Energy One way inflammation contributes to aging is through ...

  8. Hayflick limit - Wikipedia

    en.wikipedia.org/wiki/Hayflick_limit

    The typical normal human fetal cell will divide between 50 and 70 times before experiencing senescence. As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence.

  9. Science Says This Workout Can Make Your Body 8 Years ... - AOL

    www.aol.com/science-says-workout-body-8...

    (Telomeres help prevent your DNA from getting damaged, among other things, and are usually measured in biological aging.) The participants were also asked how often they worked out, including how ...