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Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
The birth defects caused by thalidomide led to the development of greater drug regulation and monitoring in many countries. [9] [11] It was approved in the United States in 1998 for use as a treatment for cancer. [6] It is on the World Health Organization's List of Essential Medicines. [12] It is available as a generic medication. [8] [13]
Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. [1] [2] A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined.
Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10] Ayurvedic Herbo-mineral (Rasashastra) Medicines Heavy metal contamination [11] Bitter orange 'Fainting, arrhythmia, heart attack, stroke, death' [4] Broom
Still used as veterinary drug and as a human antihelminthic in many markets; listed on the WHO List of Essential Medicines. In humans, it was used to treat melanoma before it was withdrawn for agranulocytosis. [29] [30] [31] Levomethadyl acetate: 2003 US Cardiac arrhythmias and cardiac arrest. [2] Lorcaserin (Belviq) 2020 US Increased risk of ...
The underlying cause often isn’t clear, but risk factors include: Down’s syndrome. Infections during pregnancy, such as rubella. Possibly taking certain medications during pregnancy, such as ...