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Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. [6][7][8] It is used an alternative to warfarin to prevent blood clots following hip or knee replacement and in those with a ...
Discovery and development of direct Xa inhibitors. Four drugs from the class of direct Xa inhibitors are marketed worldwide. Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. [1] The second one was apixaban (Eliquis), approved in Europe in 2011 [2] and in the United States ...
Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [ 8 ] It has not been found to be useful for other factor Xa inhibitors. [ 9 ] It is given by injection into a vein.
The article Bristol-Myers Squibb and Pfizer Announce U.S. FDA Approval of ELIQUIS® (apixaban) originally appeared on Fool.com. Try any of our Foolish newsletter services free for 30 days .
Medical use. Direct factor Xa inhibitors include rivaroxaban, apixaban and edoxaban, and are types of direct oral anticoagulant (DOAC), which are blood thinning drugs, one of the classes of antithrombotic drugs. [4][5][6] They are commonly prescribed to treat and prevent blood clots in veins, prevent stroke and embolism in people with non ...
Canada has a publicly funded healthcare system, which has resulted in limited specialty care resources and inconsistency with family physicians being able to order advanced diagnostic tests, ...
In the phase IIb PACIFIC clinical trial programs, asundexian consistently showed no difference in bleeding rate compared with placebo [3][4] and reduced the risk of bleeding compared with apixaban. [5] All three trials in the programs were not powered to show efficacy of asundexian. [2] However, a phase III trial, OCEANIC-AF, was stopped due to ...
The direct oral anticoagulants (DOACs) were introduced in and after 2008. [88] There are five DOACs currently on the market: dabigatran, rivaroxaban, apixaban, edoxaban and betrixaban. [89] They were also previously referred to as "new/novel" and "non-vitamin K antagonist" oral anticoagulants (NOACs).