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TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...
[15] [16] [17] The compound was being used as a vaginal antiseptic by the late 1800s. [18] Clinical studies of boric acid for treatment of vaginal infections began being published in the late 1900s and early 2000s. [5] Despite not being a pharmaceutical drug, boric acid is widely used by women in the management of vaginal infections.
Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [11] It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [11]
Results released in February 2009 from a clinical trial of PRO 2000 (Indevus Pharmaceuticals), a vaginal-microbicide gel (0.5%), sparked hope that it might provide modest protection against HIV. [22] The results of a larger trial released in December 2009 showed that PRO 2000 was safe as administered, but was ineffective in reducing the risk of ...
The ideal vaginal microbicide would have the following characteristics: provide protection against infection not require application at the time of intercourse not harm the natural tissue [3] As of 2009, not harming natural tissue was the most troublesome aspect of development.
I tried a $38 gel-manicure kit and compared it to my usual $110 professional gel set.. In a time crunch, I could see why the at-home kit could be useful, but it's a lot of work. For quality alone ...
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