Search results
Results From The WOW.Com Content Network
The cause of PML is a type of polyomavirus called the JC virus (JCV), after the initials of the person (John Cunningham) from whose tissue the virus was first successfully cultured. Publications indicate 39 [ 3 ] to 58% [ 4 ] of the general population are seropositive for antibodies to JCV, indicating current or previous infection with the virus.
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [5] of the cell nucleus.
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
This is where you would get paid twice a month, typically 15 days apart. For many, it occurs on the 1st and 15th of the month. If you’re paid bi-monthly, each month would always include two ...
For premium support please call: 800-290-4726 more ways to reach us
Last month's fee hasn’t been processed yet. This happens when your account is past due. In this case, the charge for last month’s service will post along with your current bill. At first glance, it might look as if we’re double-billing you, but in fact we weren’t able to charge you last month so we’re applying both payments to one bill.
She was diagnosed with the condition — which causes swelling due to a buildup of lymph fluid in the body — after undergoing a double mastectomy following her breast cancer diagnosis in 2012 ...
The drug was pulled off the U.S. market because of the association with PML on April 10, 2009. [citation needed] A boxed warning for brentuximab vedotin (Adcetris) was issued by the FDA on January 13, 2011 after two cases of PML were reported, bringing the total number of associated cases to three. [30]