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Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5] [7] and for the treatment of dry eye syndrome. [6] [8] It is a nicotinic acetylcholine receptor partial agonist.
In rats, this dose was 1000 mg/kg/day, which is approximately 24 times a human dose of 200 mg twice daily based on mg/m 2 /day. In rabbits, the highest dose tested was 90 mg/kg/day, which is approximately four times a human dose of 200 mg twice daily based on mg/m 2 /day. This dose produced severe maternal toxicity and resulted in fetal ...
EE levels while fasting or with a high-fat meal following ingestion of tablets containing a single oral dose of 20 μg EE and 2 mg norethisterone acetate in women. [ 145 ] [ 7 ] The oral bioavailability of EE is 45% on average, with a wide range of 20% to 74% (though most commonly between 38 and 48%) that is due to high interindividual ...
The chart was designed by Ian Bailey [5] and Jan E. Lovie-Kitchin at the National Vision Research Institute of Australia. [1] [3] They described their motivation for designing the LogMAR chart as follows: "We have designed a series of near vision charts in which the typeface, size progression, size range, number of words per row and spacings were chosen in an endeavour to achieve a ...
Estradiol/megestrol acetate (Mego-E, Chinese Injectable No. 2) Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (Sin-Ol) Estradiol benzoate butyrate/algestone acetophenide (Redimen, Soluna, Unijab) Estradiol cypionate/hydroxyprogesterone caproate (Sinbios) Estradiol cypionate/medroxyprogesterone acetate (Cyclo-Provera ...
It is often expressed in terms of mg-min/m 3. ICt 50 is the dose that will cause incapacitation rather than death. These measures are commonly used to indicate the comparative efficacy of chemical warfare agents, and dosages are typically qualified by rates of breathing (e.g., resting = 10 L/min) for inhalation, or degree of clothing for skin ...
The [A] at which E is 50% of E max is termed the half maximal effective concentration and is abbreviated EC 50, or rarely [A] 50. The term "potency" refers to the EC 50 value. The lower the EC 50 , the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency.
The Haaland equation was proposed in 1983 by Professor S.E. Haaland of the Norwegian Institute of Technology. [9] It is used to solve directly for the Darcy–Weisbach friction factor f for a full-flowing circular pipe. It is an approximation of the implicit Colebrook–White equation, but the discrepancy from experimental data is well within ...