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Effective half-life. In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination ...
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma. [1][2][3][4][5] It is denoted by the abbreviation . [2][4] This is used to measure the removal of ...
Committed dose. The committed dose in radiological protection is a measure of the stochastic health risk due to an intake of radioactive material into the human body. Stochastic in this context is defined as the probability of cancer induction and genetic damage, due to low levels of radiation. The SI unit of measure is the sievert.
In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [1]). In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used ...
Radiometric dating. Radiometric dating, radioactive dating or radioisotope dating is a technique which is used to date materials such as rocks or carbon, in which trace radioactive impurities were selectively incorporated when they were formed. The method compares the abundance of a naturally occurring radioactive isotope within the material to ...
The pharmacology of estradiol, an estrogen medication and naturally occurring steroid hormone, concerns its pharmacodynamics, pharmacokinetics, and various routes of administration. [ 10 ][ 11 ][ 12 ] Estradiol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like ...
The elimination half-life of testosterone in the blood or by intravenous injection is only about 10 minutes. [ 8 ] [ 33 ] Conversely, testosterone and testosterone esters in oil solution or crystalline aqueous suspension administered by intramuscular or subcutaneous injection have much longer half-lives, in the range of days to months, due to ...
The half-life of a radioactive isotope (usually denoted by t 1/2) is a more familiar concept than the mean-life, so although the equations above are expressed in terms of the mean-life, it is more usual to quote the value of 14 C 's half-life than its mean-life. The currently accepted value for the half-life of 14 C is 5,700 ± 30 years. [21]