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Cocaine is known to suppress hunger and appetite by increasing co-localization of sigma σ 1 R receptors and ghrelin GHS-R1a receptors at the neuronal cell surface, thereby increasing ghrelin-mediated signaling of satiety [ 123 ] and possibly via other effects on appetitive hormones. [ 124 ]
Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
Cocaine is a powerful stimulant known to make users feel energetic, cheerful, talkative, etc. In time, negative side effects include increased body temperature, irregular or rapid heart rate, high blood pressure, increased risk of heart attacks, strokes and even sudden death from cardiac arrest.
Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation. [5] Its positive effects are euphoria, stimulation, increased talkativeness and mood lift. [6] However, because the drug acts similar as cocaine, it has comparable negative side ...
Mainstream media reported cocaine epidemics as early as 1894 in Dallas, Texas. Reports of the cocaine epidemic would foreshadow a familiar theme in later so-called epidemics, namely that cocaine presented a social threat more dangerous than simple health effects and had insidious results when used by blacks and members of the lower class.
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [181] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
Cocaine, in contrast to marijuana or alcohol, is a powerful stimulant. Upon entering the bloodstream, it rapidly reaches the brain within minutes, causing a significant surge in dopamine levels. The effects of cocaine are intense but short-lived, typically lasting about 30 minutes.
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...