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High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). [1] [2] It may be referred to simply as prostatic intraepithelial neoplasia (PIN).
However, high magnification (right image) shows the key feature of prominent nucleoli (visible at 200x magnification to make the diagnosis of "high-grade"), as well as other typical features of HGPIN. Reference for features: - Margaret Sanders, M.B.B.Ch., Murali Varma, M.B.B.S.. High grade prostatic intraepithelial neoplasia (HGPIN).
IDCP associated with invasive carcinoma (IDCP-inv) generally represents a growth pattern of invasive prostatic adenocarcinoma while the rarely encountered pure IDCP is a precursor of prostate cancer. [20] The diagnostic criterion of nuclear size at least 6 times normal is ambiguous as size could refer to either nuclear area or diameter.
Prostate cancer is the most diagnosed cancer in men in over half of the world's countries, and the leading cause of cancer death in men in around a quarter of countries. [91] Prostate cancer is rare in those under 40 years old, [92] and most cases occur in those over 60 years, [2] with the average person diagnosed at 67. [93]
The symptoms of an enlarged prostate can include frequent urination and needing to get up many times in the night to pee. A man might have trouble getting started in the bathroom or dribbling when ...
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related to: hgpin prostate neoplasia symptoms pictures female body