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His experience in the areas of glucose-6-phosphate biochemistry, carbon dioxide fixation, hexokinase and phosphate studies led him to hypothesize cotransport of glucose along with sodium through the intestine. Pictured right is of Dr. Crane and his drawing of the cotransporter system he proposed in 1960, at the international meet on membrane ...
SGLT2 is only found in kidney tubules and in conjunction with SGLT1 resorbs glucose into the blood from the forming urine. By inhibiting SGLT2, and not targeting SGLT1, glucose is excreted which in turn lowers blood glucose levels. Examples include dapagliflozin (Farxiga in US, Forxiga in EU), canagliflozin (Invokana) and empagliflozin (Jardiance).
In symport, two molecule move in a 'similar direction' at the 'same time'. For example, the movement of glucose along with sodium ions. It exploits the uphill movement of other molecules from low to high concentration, which is against the electrochemical gradient for the transport of solute molecules downhill from higher to lower concentration.
6524 246787 Ensembl ENSG00000140675 ENSMUSG00000030781 UniProt P31639 Q923I7 RefSeq (mRNA) NM_003041 NM_133254 RefSeq (protein) NP_003032 NP_573517 Location (UCSC) Chr 16: 31.48 – 31.49 Mb Chr 7: 127.86 – 127.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 ...
In August 1960, in Prague, Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption. [3] Cotransport was the first ever proposal of flux coupling in biology and was the most important event concerning carbohydrate absorption in the 20th century. [4] [5]
American biochemist at the University of Medicine and Dentistry of New Jersey, known for his discovery of sodium-glucose cotransport. Francis Crick FRS (1916–2004). British molecular biologist and neuroscientist at the University of Cambridge and the Salk Institute, noted for proposing the double helical structure of DNA.
The basic function of the Na-K-Cl cotransporter (NKCC). The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. [1]
There are several known sodium-dependent phosphate transporters found in humans. For example, the protein 2A is encoded by the solute carrier family 34, member 1 (SLC34A1) gene [7] and facilitates uptake of phosphate for normal cellular functions including cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. The PNaS ...