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A wide variety of deoxyribonucleases are known and fall into one of two families (DNase I or DNase II), which differ in their substrate specificities, chemical mechanisms, and biological functions. Laboratory applications of DNase include purifying proteins when extracted from prokaryotic organisms.
Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. [5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides.
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1776 13421 Ensembl ENSG00000163687 ENSMUSG00000025279 UniProt Q13609 O55070 RefSeq (mRNA) NM_004944 NM_001256560 NM_007870 RefSeq (protein) NP_001243489 NP_004935 NP_031896 Location (UCSC) Chr 3: 58.19 – 58.21 Mb Chr 14: 14.48 – 14.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxyribonuclease gamma (also termed DNase γ, deoxyribonuclease 1L3, DNASE1L3, of ...
Diagram illustrating genomics. Omics is the collective characterization and quantification of entire sets of biological molecules and the investigation of how they translate into the structure, function, and dynamics of an organism or group of organisms.
Molecular medicine is a broad field, where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. [1]
Exodeoxyribonucleases are both exonucleases and deoxyribonucleases. They catalyze digestion of the ends of linear DNA. They are a type of esterase.
Biomedicine is the cornerstone of modern health care and laboratory diagnostics.It concerns a wide range of scientific and technological approaches: from in vitro diagnostics [7] [8] to in vitro fertilisation, [9] from the molecular mechanisms of cystic fibrosis to the population dynamics of the HIV virus, from the understanding of molecular interactions to the study of carcinogenesis, [10 ...