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Structure of a BiTE. V H: Heavy chain variable regions. V L: Light chain variable regions. Different specificity is marked with different colours and shapes. The arrows point from N-to C-terminus. Bi-specific T-cell engager (BiTE) is a class of artificial bispecific monoclonal antibodies that are investigated for use as anti-cancer drugs.
NICE publishes guidelines in four areas: the use of health technologies within England's National Health Service (NHS) (such as the use of new and existing medicines, treatments and procedures) clinical practice (guidance on the appropriate treatment and care of people with specific diseases and conditions)
The medical treatment of this injury is similar to those of a human bite, but may also involve damage of the underlying tendons. [ 4 ] These injuries should be managed as other human bites: wound irrigation and antibiotics are essential as human saliva can contain a number of bacteria. [ 5 ]
Blinatumomab linking a T cell to a malignant B cell.. Blinatumomab is a bispecific T-cell engager (BiTE). [7] It enables a patient's T cells to recognize malignant B cells. A molecule of blinatumomab combines two binding sites: a CD3 site for T cells and a CD19 site for the target B cells.
Animal bites are the most common form of injury from animal attacks. The U.S. estimated annual count of animal bites is 250,000 human bites, 1 to 2 million dog bites, 400,000 cat bites, and 45,000 bites from snakes. [2] Bites from skunks, horses, squirrels, rats, rabbits, pigs, and monkeys may be up to one percent of bite injuries.
The Haddon Matrix is the most commonly used paradigm in the injury prevention field. Developed by William Haddon in 1970, the matrix looks at factors related to personal attributes, vector or agent attributes and environmental attributes; before, during and after an injury or death. By utilizing this framework, one can then think about ...
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Human tetanus immunoglobulin injected intrathecally (which increases clinical improvement from 4% to 35%). Tracheotomy and mechanical ventilation for 3 to 4 weeks. Tracheotomy is recommended for securing the airway, because the presence of an endotracheal tube is a stimulus for spasm.
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