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Children appear to be at a high risk for cardiopulmonary arrest. A toxic dose for children of more than 1.8 mg/kg has been reported. A 3-year-old child died 18 hours after ingesting 1,000 mg doxylamine succinate. [5] Rarely, an overdose results in rhabdomyolysis and acute kidney injury. [36]
Many psychological measures for autism assess stability over time. However, with the rise of various preventative programs for autism, there is an increased need for these measures to assess change over time. [6] Additionally, not all measures orientated towards infants and toddlers are appropriate for older children as they continue to develop.
A 2018 Cochrane systematic review included 12 studies of ADOS diagnostic accuracy in pre-school children (Modules 1 and 2). The summary sensitivity was 0.94 (95% CI 0.89 to 0.97), with sensitivity in individual studies ranging from 0.76 to 0.98. The summary specificity was 0.80 (95% CI 0.68 to 0.88), with specificity in individual studies ...
The Childhood Autism Rating Scale (CARS) is a behavior rating scale intended to help diagnose autism. CARS was developed by Eric Schopler , Robert J. Reichler , and Barbara Rochen Renner . The scale was designed to help differentiate children with autism from those with other developmental delays, such as intellectual disability .
Classic autism, also known as childhood autism, autistic disorder, or Kanner's syndrome, is a formerly diagnosed neurodevelopmental disorder first described by Leo Kanner in 1943. It is characterized by atypical and impaired development in social interaction and communication as well as restricted, repetitive behaviors, activities, and interests.
The pilot study was used to discern the preliminary cutoff scores for the CAST. Parents of 13 children with Asperger syndrome and 37 typically developing children completed the CAST questionnaire. There were significant differences in average scores, with the Asperger syndrome sample average of 21.08 (range 15–31) and the typical sample ...
Other terms used to describe regression in children with autism are autism with regression, autistic regression, setback-type autism, and acquired autistic syndrome. [16] Within the regressive autism developmental course, there are two patterns. The first pattern is when developmental losses occur in the first 15 months to 3 years.
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...