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A blood smear is made by placing a drop of blood on one end of a slide, and using a spreader slide to disperse the blood over the slide's length. The aim is to get a region, called a monolayer, where the cells are spaced far enough apart to be counted and differentiated.
An initial evaluation of a suspected lymphoma is to make a "touch prep" wherein a glass slide is lightly pressed against excised lymphoid tissue, and subsequently stained (usually H&E stain) for evaluation under light microscopy. The second method of histology processing is called frozen section processing. This is a highly technical scientific ...
The H&E staining procedure is the principal stain in histology [3] [7] [2] [5] in part because it can be done quickly, [7] is not expensive, and stains tissues in such a way that a considerable amount of microscopic anatomy [9] [10] is revealed, [7] [5] [4] and can be used to diagnose a wide range of histopathologic conditions. [8]
Histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. [ 5 ] [ 6 ] It is an important part of anatomical pathology and surgical pathology , as accurate diagnosis of cancer and other diseases often requires histopathological examination of tissue samples. [ 10 ]
Simple Staining is a technique that only uses one type of stain on a slide at a time. Because only one stain is being used, the specimens (for positive stains) or background (for negative stains) will be one color. Therefore, simple stains are typically used for viewing only one organism per slide. Differential staining uses multiple stains per ...
Digital pathology is a major part of pathology informatics, and encompasses topics including slide scanning, digital imaging, image analysis and telepathology.. Digital pathology is a sub-field of pathology that focuses on managing and analyzing information generated from digitized specimen slides.
Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells [1] [2] and secrete large quantities of proteins called antibodies in response to being presented specific substances called antigens.
Usually specific surface proteins are used to identify cells, and based on this they are put into different categories. Another major effort to make an overview of these proteins that allows us to observe cell types is the Human Protein Atlas .