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ZED1227 is a transglutaminase 2 (TG2) inhibitor developed by Zedira GmbH for celiac disease [1] [2] and nonalcoholic steatohepatitis. [3] References
Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye, spelt and barley. [10]
This condition is known as refractory coeliac disease (RCD), defined as malabsorption due to gluten-related enteropathy (villous atrophy or elevated intraepitheal lymphocytes) after initial or subsequent failure of a strict gluten-free diet (usually 1 year) and after exclusion of any disorder mimicking coeliac disease.
For individuals with gluten sensitivity or celiac disease, gluten can trigger an immune response, leading to more inflammation and potentially worsening autoimmune conditions like alopecia areata ...
With bacterial infections, prompt treatment with the right antibiotic is critical. If you suspect this is the cause of your chills, see a healthcare provider right away. 8.
In 1924, Sidney V. Haas (1870–1964) described the first SCD for the treatment of children with celiac disease; this was known as the banana diet. [2] [3] Haas described a trial with 10 children; all 8 children treated with bananas went into remission, and the two control children died. [4]
Other conditions that may present similarly include celiac disease, microscopic colitis, inflammatory bowel disease, bile acid malabsorption, and colon cancer. [7] Treatment of IBS is carried out to improve symptoms. This may include dietary changes, medication, probiotics, and counseling.
Enteropathy-associated T-cell lymphoma (EATL), previously termed enteropathy-associated T-cell lymphoma, type I and at one time termed enteropathy-type T-cell lymphoma (ETTL), is a complication of coeliac disease in which a malignant T-cell lymphoma develops in areas of the small intestine affected by the disease's intense inflammation. [1]