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Gadopiclenol, sold under the brand name Elucirem among others, is a contrast agent used with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and in the body. [2] [7] Gadopiclenol is a paramagnetic macrocyclic non-ionic complex of gadolinium. [2]
Traditional gadolinium-based contrast agents are un-targeted, generally distributing throughout the body after injection, but will not readily cross the intact blood–brain barrier. [36] Brain tumors , and other disorders that degrade the blood-brain barrier, allow these agents to penetrate into the brain and facilitate their detection by ...
Clearance of a substance is sometimes expressed as the inverse of the time constant that describes its removal rate from the body divided by its volume of distribution (or total body water). In steady-state, it is defined as the mass generation rate of a substance (which equals the mass removal rate) divided by its concentration in the blood .
Clearance is therefore expressed as the plasma volume totally free of the drug per unit of time, and it is measured in units of volume per units of time. Clearance can be determined on an overall, organism level («systemic clearance») or at an organ level (hepatic clearance, renal clearance etc.). The equation that describes this concept is:
Bisphenol A (BPA), phthalates, and per- and polyfluoroalkyl substances (PFAS) are just a few of the chemicals known to imitate hormones and disrupt the body’s natural endocrine system, which is ...
Studies show that alcohol consumption, especially in excess, may disrupt the body’s immune response, leading to chronic inflammation. Cutting back on your alcohol intake can have loads of ...
MRI contrast agents are contrast agents used to improve the visibility of internal body structures in magnetic resonance imaging (MRI). [1] The most commonly used compounds for contrast enhancement are gadolinium-based contrast agents (GBCAs).
What does selenium do for the body? Selenium plays important roles in hormone function, a healthy metabolism, DNA synthesis and protection from oxidative damage and infection, ...