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The dermis is composed of three major types of cells: [3] fibroblasts, macrophages, and mast cells.. Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan ...
The skin is one of the largest organs of the body. In humans, it accounts for about 12 to 15 percent of total body weight and covers 1.5 to 2 m 2 of surface area. [1] 3D still showing human integumentary system. The skin (integument) is a composite organ, made up of at least two major layers of tissue: the epidermis and the dermis. [2]
It is formed when a dermomyotome (the remaining part of the somite left when the sclerotome migrates), splits to form the dermatome and the myotome. [2] The dermatomes contribute to the skin, fat and connective tissue of the neck and of the trunk, though most of the skin is derived from lateral plate mesoderm .
The face and neck development of the human embryo refers to the development of the structures from the third to eighth week that give rise to the future head and neck.They consist of three layers, the ectoderm, mesoderm and endoderm, which form the mesenchyme (derived form the lateral plate mesoderm and paraxial mesoderm), neural crest and neural placodes (from the ectoderm). [1]
The dermis is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and strain. The dermis provides tensile strength and elasticity to the skin through an extracellular matrix composed of collagen fibrils , microfibrils , and elastic fibers , embedded in hyaluronan and proteoglycans . [ 15 ]
The cells that migrate through the most cranial part of the primitive line form the paraxial mesoderm, which will give rise to the somitomeres that in the process of somitogenesis will differentiate into somites that will form the sclerotomes, the syndetomes, [18] the myotomes and the dermatomes to form cartilage and bone, tendons, dermis (skin ...
Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. [1] Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. [2]
For the average adult human, the skin has a surface area of 1.5–2.0 square metres (15–20 sq ft). The thickness of the skin varies considerably over all parts of the body, and between men and women, and young and old. An example is the skin on the forearm, which is on average 1.3 mm in males and 1.26 mm in females. [4]