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Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind denedyllated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. [1] The complex was originally identified in plants, [2] [3] and subsequently found in all eukaryotic organisms including human.
10987 26754 Ensembl ENSG00000121022 ENSMUSG00000025917 UniProt Q92905 O35864 RefSeq (mRNA) NM_006837 NM_001277101 NM_013715 RefSeq (protein) NP_006828 NP_006828.2 NP_001264030 NP_038743 Location (UCSC) Chr 8: 67.04 – 67.08 Mb Chr 1: 10.09 – 10.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 ...
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways.
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COP9 signalosome: Catalyses the hydrolysis of NEDD8 protein from the Cullin subunit of Cullin-RING ubiquitin ligases (CRL). Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind deneddylated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. [11]
COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene. [ 5 ] [ 6 ] This gene encodes one of eight subunits composing COP9 signalosome , a highly conserved protein complex that functions as an important regulator in multiple signaling pathways.
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COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene. [ 5 ] [ 6 ] [ 7 ] It encodes a subunit of the COP9 signalosome . Interactions