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Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind denedyllated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. [1] The complex was originally identified in plants, [2] [3] and subsequently found in all eukaryotic organisms including human.
10987 26754 Ensembl ENSG00000121022 ENSMUSG00000025917 UniProt Q92905 O35864 RefSeq (mRNA) NM_006837 NM_001277101 NM_013715 RefSeq (protein) NP_006828 NP_006828.2 NP_001264030 NP_038743 Location (UCSC) Chr 8: 67.04 – 67.08 Mb Chr 1: 10.09 – 10.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 ...
Print/export Download as PDF; Printable version; In other projects ... COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene. [5]
COP9 signalosome: Catalyses the hydrolysis of NEDD8 protein from the Cullin subunit of Cullin-RING ubiquitin ligases (CRL). Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind deneddylated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. [11]
The conference included the 9th Conference of the Parties (COP9) to the United Nations Framework Convention on Climate Change (UNFCCC). The parties agreed to use the Adaptation Fund established at COP7 in 2001 primarily in supporting developing countries better adapt to climate change. The fund would also be used for capacity-building through ...
Print/export Download as PDF; Printable version; In other projects ... COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene ...