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Catabolite Activator Protein (blue) bound to a piece of DNA (red). In cell biology, catabolite activator protein (CAP), which is also known as cAMP receptor protein (CRP), is a trans-acting transcriptional activator in bacteria that effectively catalyzes the initiation of DNA transcription by interacting with RNA polymerase in a way that causes the DNA to bend.
The structures of CaP and sodium peroxide (Na 2 O 2) are very similar. [1] The solid is described as a salt: (Ca 2+) 2 P 2 4−, or Ca 2 P 2. Since the bonding is ionic, the diphosphide centers carry negative charge and are easily protonated. Upon hydrolysis this material releases diphosphine (P 2 H 4): [2] Ca 2 P 2 + 4 H 2 O → 2 Ca(OH) 2 + P ...
Examples of the capped octahedral molecular geometry are the heptafluoromolybdate (MoF − 7) and the heptafluorotungstate (WF − 7) ions. [3] [4] The "distorted octahedral geometry" exhibited by some AX 6 E 1 molecules such as xenon hexafluoride (XeF 6) is a variant of this geometry, with the lone pair occupying the "cap" position.
Molecular Biology of the Cell is a biweekly peer-reviewed scientific journal published by the American Society for Cell Biology. It covers research on the molecular basis of cell structure and function. According to the Journal Citation Reports, the journal has a 2012 impact factor of 4.803. [1] It was originally established as Cell Regulation ...
The origins of the ISMB conference lie in a workshop for artificial intelligence researchers with an interest in molecular biology held in November 1991. [3] The workshop was organised by American researcher Lawrence Hunter, then director of the Machine Learning Project at the United States National Institutes of Health's National Library of Medicine (NLM) in Bethesda, Maryland. [4]
In 2013, Batut et al. [13] combined CAP trapper, template switching, and 5′-phosphate-dependent exonuclease digestion in RAMPAGE to maximize promoter specificity. In 2014, Murata et al. [ 14 ] published the nAnTi-CAGE protocol, where capped 5′ ends are sequenced on the Illumina platform with no PCR amplification and no tag cleavage.
This phenomenon, the process of which is called cap formation, was discovered in 1971 on lymphocytes [1] and is a property of amoebae and all locomotory animal cells except sperm. The crosslinking is most easily achieved using a polyvalent antibody to a surface antigen on the cell.
The Association for Molecular Pathology is a 501(c)(3) non-profit scientific society that advances the clinical practice, science, and excellence of molecular and genomic laboratory medicine through education, innovation, and advocacy to enable the highest quality health care.