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Signs and symptoms arising from liver damage in Alagille syndrome may include a yellowish tinge in the skin and the whites of the eyes (), itching (), pale stools (), an enlarged liver (hepatomegaly), an enlarged spleen (splenomegaly) and deposits of cholesterol in the skin (). [9]
Biliary atresia, also known as extrahepatic ductopenia and progressive obliterative cholangiopathy, is a childhood disease of the liver in which one or more bile ducts are abnormally narrow, blocked, or absent. It can be congenital or acquired. Biliary atresia is the most common reason for pediatric liver trasplantation in the United States. [2]
Genetic liver disease: A genetic disorder, known as alagille syndrome, which presents by the age of two, can affect the liver, the heart, and other parts of the body. The symptoms of any of these ...
The most commonly associated symptoms of jaundice are itchiness, [2] pale feces, and dark urine. [4] Normal levels of bilirubin in blood are below 1.0 mg/dl (17 μmol/L), while levels over 2–3 mg/dl (34–51 μmol/L) typically result in jaundice. [4] [9] High blood bilirubin is divided into two types: unconjugated and conjugated bilirubin. [10]
This disease is marked by increased extravascular hemolysis, with laboratory findings including increased lactate dehydrogenase and decreased or absent haptoglobin in both warm and cold AIHA, and positive Coombs test. [5] Clinically, jaundice or dark urine present in approximately one-third of the cases, and most of the symptoms are related to ...
Genetic liver disease: Alagille syndrome is a genetic disorder, present by the age of two, that affects the liver, the heart, and other parts. The symptoms of any of these liver problems may ...
The classic symptoms of liver damage include the following: Pale stools occur when stercobilin, a brown pigment, is absent from the stool. Stercobilin is derived from bilirubin metabolites produced in the liver. Dark urine occurs when bilirubin mixes with urine
Other causes of chronic liver disease are genetic or autoimmune disease, such as hemochromatosis, Wilson's disease, autoimmune hepatitis, and primary biliary cirrhosis. [5]: 959–963, 971 Acute liver disease rarely results in pain, but may result in jaundice. Infectious liver disease may cause a fever.