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Ibuprofen is a weaker anti-inflammatory agent than other NSAIDs. [10] Ibuprofen was discovered in 1961 by Stewart Adams and John Nicholson [12] while working at Boots UK Limited and initially marketed as Brufen. [13] It is available under a number of brand names including Advil, Motrin, and Nurofen.
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An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
Ibuprofen: rat, oral 636 mg/kg 0.636 [34] Formaldehyde (CH 2 O) rat, oral 600–800 mg/kg 0.6 [35] Solanine (main alkaloid in the several plants in Solanaceae amongst them Solanum tuberosum) rat, oral (2.8 mg/kg human, oral) 590 mg/kg 0.590 [36] Alkyl dimethyl benzalkonium chloride (ADBAC) rat, oral fish, immersion aquatic invertebrates, immersion
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The profens are a class of nonsteroidal anti-inflammatory drugs. [1] Profens are also known as 2-arylpropionic acids to reflect their chemical structure. [2] The most common example of a profen is ibuprofen, which has been sold under the brand name Profen among others.