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Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5] [6] [7]MUC-5AC is a large gel-forming glycoprotein.In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance.
The major mucins secreted – MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic properties. [7] [4] MUC5AC is the main gel-forming mucin secreted by goblet cells, in the form of threads and thin sheets. MUC5B is a polymeric protein secreted from submucosal glands and some goblet cells, and this is in the ...
Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis , which may be important in maintaining mucosal barriers.
The excessive mucus production seen in allergic asthma patients is due to goblet cell metaplasia, the differentiation of airway epithelial cells into mucin producing goblet cells. [17] These cells produce the thick mucins MUC5AC and MUC5B, which clog the airway, leading to the airflow obstruction characteristic of asthma. [17]
Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium. [ 12 ] 15-Lipoxygenase-1 (15LO1) which is an enzyme in the fatty acid metabolism and its metabolite, 15-HETE, are highly expressed in asthma (which lead to the overexpression of MUC5AC) and are induced by IL-13 in human airway ...
74180 Ensembl ENSG00000117983 ENSMUSG00000066108 UniProt Q9HC84 n/a RefSeq (mRNA) NM_002458 NM_028801 RefSeq (protein) NP_002449 n/a Location (UCSC) Chr 11: 1.22 – 1.26 Mb Chr 7: 141.39 – 141.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by the Muc5b gene in the mouse. It is one of the five gel ...
Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene encoding a protein of the same name. [5] MUC6, along with MUC2, MUC5AC, and MUC5B, is located within the 11p15 chromosomal locus of chromosome 11. MUC6, along with MUC1, is expressed in normal pancreases. [6]
Olfactory glands, also known as Bowman's glands, are a type of nasal gland situated in the part of the olfactory mucosa beneath the olfactory epithelium, that is the lamina propria, a connective tissue also containing fibroblasts, blood vessels and bundles of fine axons from the olfactory neurons.