Ads
related to: parp inhibitor meaning medical definition- About PARP Inhibitors
Learn About How Treatment Works.
Learn About Maintenance Therapy.
- Treatment Effectiveness
Read About How Treatment Works And
Its Benefits And Risks In Patients.
- Safety And Side Effects
Read Important Safety Information.
Learn More About A Treatment.
- Tablet Dosing Info
Learn About Tablet Dosing For
An Ovarian Cancer Treatment.
- Talk To Your Doctor
Get Resources To Help Stay Informed
To Make Your Conversation Easier.
- First-Line Maintenance
Learn About First-Line Treatment.
Download Helpful Resources & Info.
- About PARP Inhibitors
Search results
Results From The WOW.Com Content Network
PARP inhibitors are a call of drugs that are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP), which plays a role in repairing DNA in damaged cells. Medical uses of these drugs include the treatment of heritable cancers . [ 1 ]
Thus, PARP inhibitors of various types (e.g. olaparib) for BRCA mutant breast and ovarian cancers can extend beyond these tumors if appropriate biomarkers can be developed to identify HRR defects. There are several additional classes of novel PARP inhibitors that are in various stages of clinical development. [21]
[48] [49] These findings provided explanation for previous and subsequent reports demonstrating tissue protective effects of PARP inhibitors and the PARP1 knockout phenotypes in various models of ischemia-reperfusion injury (e.g. in stroke, in the heart and in the gut) where oxidative stress-induced cell death is a central cellular event. [50]
Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults.It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
The link between MPTP and PARP was found later when research showed that the MPTP effects on neurons were reduced in mutated cells lacking the PARP gene. [29] The same research also showed highly increased PARP activation in dopamine producing cells in the presence of MPTP. Alpha-synuclein is a protein that binds to DNA and modulates DNA repair ...
Veliparib (ABT-888) [1] is a potential anti-cancer drug acting as a PARP inhibitor.It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
PARP may refer to: Poly ADP ribose polymerase, an enzyme; Procyclic acidic repetitive protein, a type of protein in Trypanosoma parasites; Parp (onomatopoeic), a sound
Ad
related to: parp inhibitor meaning medical definition