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A clinical control group can be a placebo arm or it can involve an old method used to address a clinical outcome when testing a new idea. For example in a study released by the British Medical Journal, in 1995 studying the effects of strict blood pressure control versus more relaxed blood pressure control in diabetic patients, the clinical control group was the diabetic patients that did not ...
Stateville Penitentiary Malaria Study – a controlled study of the effects of malaria on the inmates of Stateville Penitentiary near Joliet, Illinois. Tuskegee Study of Untreated Syphilis in the Negro Male – a clinical study, conducted between 1932 and 1972 in Tuskegee, Alabama studied the natural progression of the disease if left untreated.
Advantages of cluster-randomised controlled trials over individually randomised controlled trials include: The ability to study interventions that cannot be directed toward selected individuals (e.g., a radio show about lifestyle changes) and the ability to control for "contamination" across individuals (e.g., one individual's changing behaviors may influence another individual to do so).
The main disadvantage with between-group designs is that they can be complex and often require a large number of participants to generate any useful and reliable data. For example, researchers testing the effectiveness of a treatment for severe depression might need two groups of twenty patients for a control and a test group. If they wanted to ...
If the treatment group and the negative control both produce a positive result, it can be inferred that a confounding variable is involved in the phenomenon under study, and the positive results are not solely due to the treatment. In other examples, outcomes might be measured as lengths, times, percentages, and so forth.
To control for nuisance variables, researchers institute control checks as additional measures. Investigators should ensure that uncontrolled influences (e.g., source credibility perception) do not skew the findings of the study. A manipulation check is one example of a control check. Manipulation checks allow investigators to isolate the chief ...
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A wait list control group, also called a wait list comparison, is a group of participants included in an outcome study that is assigned to a waiting list and receives intervention after the active treatment group. This control group serves as an untreated comparison group during the study, but eventually goes on to receive treatment at a later ...