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Mitral regurgitation, also known as mitral insufficiency or mitral incompetence, is the backward flow of blood from the left ventricle, through the mitral valve, and into the left atrium, when the left ventricle contracts, resulting in a systolic murmur radiating to the left armpit.
Degenerative (myxomatous) mitral valve disease* is a common cause of congestive heart failure in dogs, especially small, older dogs. [48] The leaflets of the valve become thickened and nodular, leading to mitral valve regurgitation and volume overload of the left side of the heart.
The disease and symptoms are similar to progression of acquired valve disease in older dogs. Valve leakage leads to heart enlargement, arrhythmias, and congestive heart failure. Heart valve dysplasia can be tolerated for years or progress to heart failure in the first year of life. Diagnosis is with an echocardiogram.
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]
The anterior mitral valve moves anteriorly during systole in these patients leading to dynamic LVOTO, and the increased mass of the septum leads to a physical narrowing for blood to pass through. Thus, both of these contribute to the left ventricular outflow tract obstruction seen in some cases of this disease.
Valve surgery: If an enlarged heart is caused by a problem with a heart valve, surgery can remove the valve and replace it with either an artificial valve or a tissue valve from a pig, cow or deceased human donor. If blood leaks backward through a valve (valve regurgitation), the leaky valve may be surgically repaired or replaced.
While heart disease is common in dogs generally – one in 10 of all dogs will eventually have heart problems – mitral valve disease is generally (as in humans) a disease of old age. The "hinge" on the heart's mitral valve loosens and can gradually deteriorate, along with the valve's flaps, causing a heart murmur (as blood seeps through the ...
Degenerative valve disease is the most common form of heart disease in dogs. [25] Mitral regurgitation leads to turbulent blood flow and increased pressure in the left atrium. This causes increased pressure in the pulmonary blood vessels and pulmonary edema (a build-up of fluid in the lungs).
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