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Trimethyltrienolone (TMT), also known by its developmental code name R-2956 or RU-2956, is an antiandrogen medication which was never introduced for medical use but has been used in scientific research.
α,N,N-Trimethyltryptamine (α,N,N-TMT, α-TMT, ATMT) is a psychoactive drug of the tryptamine chemical class which acts as a psychedelic hallucinogen.It is similar in structure to the other psychedelics of the tryptamine class such as dimethyltryptamine (DMT) and α-methyltryptamine (α-MT).
4-HO-TMT is a quaternary trimethyl ammonium compound, and as a result, is less likely to be able to cross the blood–brain barrier (BBB) and enter the central nervous system than other tryptamines. [ 1 ] [ 4 ] Accordingly, 4-HO-TMT showed no ability to cross an artificial BBB-like membrane in a study. [ 2 ]
2,N,N-trimethyltryptamine, 2,N,N-TMT, or 2-Me-DMT is a tryptamine derivative that is a psychedelic drug. It was invented by Alexander Shulgin and reported in his book TiHKAL (#34). [ 1 ]
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NMT is known to act as a potent serotonin 5-HT 2A receptor full agonist (EC 50 Tooltip half-maximal effective concentration = 50.7 nM; E max Tooltip maximal efficacy = 96%). [5] It has been reported to be inactive in activating the β-arrestin pathway of the receptor and hence appears to be a biased agonist of the serotonin 5-HT 2A receptor. [5]
The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT 1A and 5-HT 2A receptors among others. [ 1 ] [ 4 ] [ 8 ] However, 5-MeO-DMT differs from most other serotonergic psychedelics in having 100- to 1,000-fold higher affinity for the serotonin 5-HT 1A receptor over the serotonin 5-HT 2A receptor.