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Levoamphetamine [note 1] is a stimulant medication which is used in the treatment of certain medical conditions. [10] It was previously marketed by itself under the brand name Cydril, but is now available only in combination with dextroamphetamine in varying ratios under brand names like Adderall and Evekeo.
This is the origin of the D/L and R/S notations, and the employment of prefixes levo-and dextro-in common names. The prefix ar-, from the Latin recto (right), is applied to the right-handed version; es-, from the Latin sinister (left), to the left-handed molecule. Example: ketamine, arketamine, esketamine. [13]
Dextroamphetamine (INN: dexamfetamine) is a potent central nervous system (CNS) stimulant and enantiomer [note 1] of amphetamine that is indicated in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Levmetamfetamine is excreted in urine 40.8 to 49.0% as unchanged levmetamfetamine and 2.1 to 3.3% as levoamphetamine. [2] [4] [3] The mean elimination half-life of levmetamfetamine ranges between 10.2 and 15.0 hours. [2] [4] For comparison, the elimination half-life of dextromethamphetamine was around 10.2 to 10.7 hours in the same studies.
Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. [note 2] Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt ...
Some two-wheeled designs had pedals mounted on the front wheel, while three- and four-wheeled designs sometimes used treadles and levers to drive the rear wheels. The earliest usable and much-copied velocipede was created by the German Karl Drais and called a Laufmaschine (German for "running machine"), which he first rode on June 12, 1817.
Tall bike (often called an upside down bike, constructed so that the pedals, seat and handlebars are all higher than normal)—other types of tall bikes are made by welding two or more bicycle frames on top of each other, and running additional chains from the pedals to the rear wheel. Come-apart bike, (essentially a unicycle, plus a set of ...
A single Adderall dose combines the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextro isomer of amphetamine saccharate and D/L-amphetamine aspartate monohydrate. The original Benzedrine was a racemic mixture, and isolated dextroamphetamine was later introduced to the market as Dexedrine.