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The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [ 1 ]
A simple bowel management technique might include diet control and establishing a toilet routine. [1] As a more involved practice a person might use an enema to relieve themselves. [1] Without bowel management, the person might either suffer from the feeling of not getting relief, or they might soil themselves. [1]
FGIDs share in common any of several physiological features including increased motor reactivity, enhanced visceral hypersensitivity, altered mucosal immune and inflammatory function (associated with bacterial dysbiosis), and altered central nervous system and enteric nervous system (CNS-ENS) regulation.
Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
Lubricant laxatives are substances that coat the stool with slippery lipids and decrease colonic absorption of water so the stool slides through the colon more easily. Lubricant laxatives also increase the weight of stool and decrease intestinal transit time. [9] Properties. Site of action: colon; Onset of action: 6–8 hours; Example: mineral ...
Without bowel management, such persons might either suffer from the feeling of not getting relief, or they might soil themselves. [ 52 ] While simple techniques might include a controlled diet and establishing a toilet routine, [ 52 ] a daily enema can be taken to empty the colon, thus preventing unwanted and uncontrolled bowel movements that day.