Ads
related to: beta thalassemia minor lab results pdf file- Symptoms Of Beta-Thal
Discover The Possible Symptoms Of
Life With Beta-Thalassemia.
- What Is Beta-Thal?
Learn More About Beta-Thalassemia
And How It May Be Impacting You.
- What Causes Beta-Thal?
Beta-Thal Affects Your Body At
The Genetic Level. Learn More.
- Beta-Thalassemia Quiz
Take The Quiz & See How Beta-Thal
May Be Impacting Your Life.
- Types Of Beta-Thalassemia
Learn About Minor, Major, &
Intermedia Beta-Thalassemia Types.
- Beta-Thalassemia Video
Watch A Video From A Family Also
Experiencing Life With Beta-Thal.
- Symptoms Of Beta-Thal
Search results
Results From The WOW.Com Content Network
Beta thalassemias ( β thalassemias) are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. Global annual incidence is estimated at one in 100,000. [4]
Hemoglobin electrophoresis is a blood test that can detect different types of hemoglobin. The test can detect hemoglobin S, the form associated with sickle cell disease, as well as other abnormal types of hemoglobin, such as hemoglobin C. It can also be used to investigate thalassemias, which are disorders caused by defective hemoglobin production.
In beta thalassemia, an increase in hemoglobin A2 results, but the co-existence of a delta-beta thalassemia mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia trait. Diagnosis. Following the detection of hypochromic microcytic red blood cells, delta-beta thalassemia ...
Additionally, individuals with beta-thalassemia exhibit a high red cell count and low hemoglobin levels. Individuals that express lower levels of hemoglobin A2, have the a 0-thalassemia trait or homozygous gene for a +-thalassemia. Laboratory methods. Hemoglobin A2 is a crucial role for screening and measuring for the beta-thalassemia trait.
Mentzer index. Purpose. in differentiating iron deficiency anemia from beta thalassemia. The Mentzer index, described in 1973 by William C. Mentzer, [1] is the MCV divided by the RBC count. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait. [2] [3]
The excess chains that fail to incorporate into Hb form non-functional aggregates that precipitate within the RBC. This can lead to premature RBC destruction in the bone marrow (beta thalassemia) and/or in the peripheral blood (alpha thalassemia). Types: [citation needed] Alpha; Beta (Major) Beta (Minor) Hemoglobin variants
β thalassemia intermedia is caused by a β + /β o or β + /β + genotype. In this form, some hemoglobin A is produced; β thalassemia minor is caused by a β/β o or β/β + genotype. Only one of the two β globin alleles contains a mutation, so β chain production is not terribly compromised and patients may be relatively asymptomatic.
Beta thalassemia minor results in a mild microcytic anemia that is often asymptomatic or may cause fatigue and or pale skin. Beta thalassemia major occurs when a person inherits two abnormal alleles. This can be either two β+ alleles, two β0 alleles, or one of each. Beta thalassemia major is a severe medical condition.
Ads
related to: beta thalassemia minor lab results pdf file