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Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment. The major function of alkaline phosphatase is transporting chemicals across cell membranes. [1]
Alkaline phosphatase is often elevated in pregnancy due to production from the placenta, but may be additionally elevated. [4] Other abnormalities may include an elevated white blood cell count , hypoglycemia , elevated coagulation parameters, including the international normalized ratio , and decreased fibrinogen .
The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found in the periplasmic ...
Alkaline phosphatase, placental type is a membrane-bound glycosylated dimeric enzyme, also referred to as the heat-stable form, that is expressed primarily in the placenta, although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. [7]
Standard liver tests for assessing liver damage include alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Bilirubin may be used to estimate the excretory function of the liver and coagulation tests and albumin can be used to evaluate the metabolic activity of the liver.
During pregnancy, hepatitis A can cause placental abruption, premature rupture of membranes, and increased rates of preterm labor. [ 20 ] Hepatitis B is an enveloped, double stranded DNA virus that is spread by exposure to blood, with the main modes of transmission are blood, sexual transmission, or perinatal.
Chad Duell is leaving General Hospital with a bang.. The Jan. 6 episode of the long-running soap opera marked the beginning of the 37-year-old actor's exit storyline when his character Michael ...
ICP is characterized by severe pruritus and elevated serum levels of bile acids as well as transaminases and alkaline phosphatase. [61] These signs and symptoms resolve on their own shortly after delivery, though they may reappear in subsequent pregnancies for 45–70% of women. [62]
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