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Other non-FDA-approved uses include actinic keratosis, amyloidosis, Peyronie's disease, and psoriasis. Dexamethasone and betamethasone in premature labor, to enhance pulmonary maturation of the fetus. [7] Doxepin has been used to treat angiodema and severe allergic reactions due to its strong antihistamine properties. [8]
H 1-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition. The authors of the American College of Chest Physicians Updates on Cough Guidelines (2006) recommend that, for cough associated with the common cold, first-generation antihistamine-decongestants are ...
Fexofenadine, sold under the brand name Allegra among others, [10] is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria. [ 11 ] Therapeutically, fexofenadine is a selective peripheral H 1 blocker .
Doxepin is a highly potent antihistamine, with this being its strongest activity. [ 49 ] [ 53 ] [ 57 ] [ 8 ] In fact, doxepin has been said to be the most or one of the most potent H 1 receptor antagonists available, with one study finding an in vitro K i of 0.17 nM. [ 37 ]
Loratadine is a tricyclic antihistamine, which acts as a selective inverse agonist of peripheral histamine H 1 receptors. [22] [26] The potency of second generation histamine antagonists is (from strongest to weakest) desloratadine (K i 0.4 nM) > levocetirizine (K i 3 nM) > cetirizine (K i 6 nM) > fexofenadine (K i 10 nM
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. [1] Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. [1]
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