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Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. [4] It is used to treat cancer , autoimmune diseases , and ectopic pregnancies . [ 4 ] Types of cancers it is used for include breast cancer , leukemia , lung cancer , lymphoma , gestational trophoblastic disease , and osteosarcoma . [ 4 ]
The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. [ 9 ] [ 10 ] A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. [ 11 ]
Rarely drug induced liver disease from methotrexate, amiodarone, nitrofurantoin and others; Paracetamol (acetaminophen) causes acute liver damage. Metabolic. Non-alcoholic fatty liver disease; Haemochromatosis; Wilson's disease; Autoimmune response causes. Primary biliary cholangitis (previously known as primary biliary cirrhosis) Primary ...
The National Institutes of Health, [65] the National Cancer Institute, [66] Cancer Research, [67] the American Cancer Society, [68] the Mayo Clinic, [69] and the Colorectal Cancer Coalition, [70] American Society of Clinical Oncology [71] and the Memorial Sloan-Kettering Cancer Center [72] list alcohol as a risk factor.
Abstinence: Stopping further alcohol consumption is the number one factor for recovery in patients with alcoholic hepatitis. [ 16 ] Nutrition Supplementation: Protein and calorie deficiencies are seen frequently in patients with alcoholic hepatitis, and it negatively affects their outcomes.
Methotrexate is commonly associated with dose-related toxic effects involving the bone marrow and gastrointestinal tract. [12] Folic acid may be given weekly to help diminish the frequency of side-effects. [12] Methotrexate is also associated with acute and chronic liver damage. Other adverse effects include: [12] Life-threatening Interstitial ...