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Staphylococcus epidermidis is a Gram-positive bacterium, and one of over 40 species belonging to the genus Staphylococcus. [1] It is part of the normal human microbiota , typically the skin microbiota , and less commonly the mucosal microbiota and also found in marine sponges.
PSMs were first discovered in S. epidermidis by Seymour Klebanoff via hot-phenol extraction and were described as a pro-inflammatory complex of three peptides. [2] Since their initial discovery, numerous roles of PSMs have been identified. However, due in part to the small size of many PSMs, they have largely gone unnoticed until recent years.
Staphylococcus epidermidis and Staphylococcus aureus were thought from cultural based research to be dominant. However 16S ribosomal RNA research finds that while common, these species make up only 5% of skin bacteria. However, skin variety provides a rich and diverse habitat for bacteria.
Staphylococcus is a genus of Gram-positive bacteria in the family Staphylococcaceae from the order Bacillales. Under the microscope, they appear spherical , and form in grape-like clusters. Staphylococcus species are facultative anaerobic organisms (capable of growth both aerobically and anaerobically).
The first discovered enzyme of this family, and the most well characterized, was isolated from the Staphylococcus aureus strain V8, and hence better known as "V8 protease". Other common references to this protease are staphylococcal serine protease, and SspA from its corresponding gene. [1] [2] [3] S. epidermidis glutamyl endopeptidase GluSE [1 ...
Methicillin was discovered in 1960. ... to treat infections caused by certain gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis, ...
S. epidermidis, a coagulase-negative staphylococcus species, is a commensal of the skin, but can cause severe infections in immune-suppressed patients and those with central venous catheters. S. saprophyticus , another coagulase -negative species that is part of the normal vaginal flora , is predominantly implicated in uncomplicated lower ...
Whether this is a root causality, just opportunistic and a side effect, or a more complex pathological duality between C. acnes and this particular Staphylococcus species is not known. [24] Current research has pointed to the idea that C. acnes and S. epidermidis have a symbiotic relationship. [25]