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Esophageal cancer; Other names: Oesophageal cancer: Endoscopic image of an esophageal adenocarcinoma: Specialty: Gastroenterology General surgery oncology: Symptoms: Difficulty swallowing, weight loss, hoarse voice, enlarged lymph nodes around the collarbone, vomiting blood, [1] blood in the stool
Oesophagogastric junctional adenocarcinoma (OGJ adenocarcinoma) is a cancer of the lower part of the oesophagus with a rising incidence in Western countries. [1] This disease is often linked to Barrett's oesophagus. H&E stain of esophageal adenocarcinoma
Barrett's esophagus is the dominant pre-malignant lesion of esophageal adenocarcinoma, [18] and has prevalent epigenetic alterations. [19] Esophageal squamous-cell carcinomas may occur as second primary tumors associated with head and neck cancer, due to field cancerization (i.e. a regional reaction to long-term carcinogenic exposure).
Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name—however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the ...
The incidence of esophageal adenocarcinoma has increased substantially in the Western world in recent years. [1] The condition is found in 5–15% of patients who seek medical care for heartburn (gastroesophageal reflux disease, or GERD), although a large subgroup of patients with Barrett's esophagus are asymptomatic.
Many people experience a burning sensation in their chest occasionally, caused by stomach acids refluxing into the esophagus, normally called heartburn. Extended exposure to heartburn may erode the lining of the esophagus, leading potentially to Barrett's esophagus which is associated with an increased risk of adenocarcinoma most commonly found ...
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