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Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized swelling caused by a compromised lymphatic system. [2] The lymphatic system functions as a critical portion of the body's immune system and returns interstitial fluid to the bloodstream .
Complications are either directly caused by obesity or indirectly related through mechanisms sharing a common cause such as a poor diet or a sedentary lifestyle. The strength of the link between obesity and specific conditions varies. One of the strongest is the link with type 2 diabetes. Excess body fat underlies 64% of cases of diabetes in ...
Lymphedema is a buildup of lymph in the interstitial space as a result of an obstruction in the lymphatic system, which can cause edema, inflammation, and fibrosis in the tissues. Lymphedema can be primary, when it occurs alone, or secondary, when it occurs as a result of another disease like filariasis or cancer.
Climbing obesity rates around the world aren't a concern; they've now become a full-fledged problem. Source: Centers for Disease Control & Prevention. In the "Global Burden of Disease" report from ...
For these people, obesity is a risk factor and should be addressed as such to reduce the risk of chronic conditions developing, but they do not yet have medical complications caused by obesity.
The cause is unknown but is believed to involve genetic and hormonal factors that regulate the lymphatic system, thus blocking the return of fats to the bloodstream. [2] It often runs in families. [ 2 ] [ 3 ] Other conditions that may present similarly include lipohypertrophy , chronic venous insufficiency , and lymphedema . [ 2 ]
Histological examination showed hyperkeratosis, marked papillomatosis, proliferation of capillaries in the upper dermis, and lymphectasia in the lower dermis. It was suspected that obesity and the preceding psoriatic lesions caused local lymphatic disturbances, followed by the development of stasis papillomatosis. [7]
Certain drugs (for example, amlodipine) can cause pedal edema. Cerebral edema is extracellular fluid accumulation in the brain. [1] It can occur in toxic or abnormal metabolic states and conditions such as systemic lupus or reduced oxygen at high altitudes. It causes drowsiness or loss of consciousness, leading to brain herniation and death.