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A problem with illegal cocaine use, especially in the higher volumes used to combat fatigue (rather than increase euphoria) by long-term users, is the risk of ill effects or damage caused by the compounds used in adulteration.
Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
These results suggested that this promoter is activated by acute cocaine use and possibly means that the neurons it regulates fire rapidly during acute cocaine exposure, yet are not affected by long-term use. BDNF has been implicated as a critical regulator in drug dependency, and Cdk5 is implicated in the regulation of cell proliferation genes ...
Stimulant use disorder is a type of substance use disorder where the use of stimulants caused clinically significant impairment or distress. It is defined in the DSM-5 as "the continued use of amphetamine -type substances, cocaine , or other stimulants leading to clinically significant impairment or distress, from mild to severe". [ 1 ]
In drug addiction, the drug-seeking behaviors become reinforced by the rush of dopamine that follows the administration of a drug of abuse. The effects of drugs of abuse on the ventral tegmental area (VTA) and the nucleus accumbens (NAc) have been studied extensively. [16]
[3] [4] [5] Methamphetamine psychosis, or long-term effects of stimulant use in the brain (at the molecular level), depend upon genetics and may persist for months or years. [6] Psychosis may also result from withdrawal from stimulants, particularly when psychotic symptoms were present during use. [7]
Cocaine dependence is a neurological disorder that is characterized by withdrawal symptoms upon cessation from cocaine use. [1] It also often coincides with cocaine addiction which is a biopsychosocial disorder characterized by persistent use of cocaine and/or crack despite substantial harm and adverse consequences.
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...