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A Michael reaction is used as a mechanistic step by many covalent inhibitor drugs. Cancer drugs such as ibrutinib, osimertinib, and rociletinib have an acrylamide functional group as a Michael acceptor. The Michael donor on the drug reacts with a Michael acceptor in the active site of an enzyme. This is a viable cancer treatment because the ...
The normal 88 keys were numbered 1–88, with the extra low keys numbered 89–97 and the extra high keys numbered 98–108. A 108-key piano that extends from C 0 to B 8 was first built in 2018 by Stuart & Sons. [4] (Note: these piano key numbers 1-108 are not the n keys in the equations or the table.)
The Stork enamine alkylation involves the addition of an enamine to a Michael acceptor (e.g., an α,β -unsaturated carbonyl compound) or another electrophilic alkylation reagent to give an alkylated iminium product, which is hydrolyzed by dilute aqueous acid to give the alkylated ketone or aldehyde. [1]
NEM is a Michael acceptor in the Michael reaction, which means that it adds nucleophiles such as thiols. The resulting thioether features a strong C-S bond and the reaction is virtually irreversible. Reaction with thiols occur in the pH range 6.5–7.5, NEM may react with amines or undergo hydrolysis at a more alkaline pH.
Pressing a key on the keyboard makes the instrument produce sounds—either by mechanically striking a string or tine (acoustic and electric piano, clavichord), plucking a string (harpsichord), causing air to flow through a pipe organ, striking a bell , or activating an electronic circuit (synthesizer, digital piano, electronic keyboard).
Musical symbols are marks and symbols in musical notation that indicate various aspects of how a piece of music is to be performed. There are symbols to communicate information about many musical elements, including pitch, duration, dynamics, or articulation of musical notes; tempo, metre, form (e.g., whether sections are repeated), and details about specific playing techniques (e.g., which ...
A food safety expert weighs in on flour bugs, also known as weevils, that can infest your pantry after one TikToker found her flour infested with the crawlers.
Action can refer to that of a piano or other musical keyboards, including the electronic or digital stage piano and synthesizer, on which some models have "weighted keys", which simulate the touch and feel of an acoustic piano. The design of the key action mechanism determines the "weight" of the keys, i.e., the force required to sound a note ...