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  2. Megaloblastic anemia - Wikipedia

    en.wikipedia.org/wiki/Megaloblastic_anemia

    Megaloblastic anemia is a type of macrocytic anemia. An anemia is a red blood cell defect that can lead to an undersupply of oxygen. [1] Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. [2] When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M ...

  3. Imerslund–Gräsbeck syndrome - Wikipedia

    en.wikipedia.org/wiki/Imerslund–Gräsbeck_syndrome

    Imerslund–Gräsbeck syndrome is a rare autosomal recessive, familial form of vitamin B12 deficiency caused by malfunction of the "Cubam" receptor located in the terminal ileum. This receptor is composed of two proteins, amnionless (AMN), and cubilin. A defect in either of these protein components can cause this syndrome.

  4. List of hematologic conditions - Wikipedia

    en.wikipedia.org/wiki/List_of_hematologic_conditions

    Macrocytic anemia: Megaloblastic anemia: D51.1, D52.0, D53.1: 29507: Megaloblastic anemia (or megaloblastic anaemia) is an anemia of macrocytic classification that results from inhibition of DNA synthesis in red blood cell production. [10] Microangiopathic hemolytic anemia: Minkowski-Chauffard syndrome: Myelophthisic anemia: D61.9

  5. Macrocytic anemia - Wikipedia

    en.wikipedia.org/wiki/Macrocytic_anemia

    Macrocytic anemias have several causes but with the implementation of folic acid fortification in North America, folate deficiency has become a rare cause of megaloblastic macrocytic anemia in that part of the world. [1] In this region, Vitamin B 12 deficiency is a far more common cause of megaloblastic macrocytic anemia. [1]

  6. Lubani Al Saleh Teebi syndrome - Wikipedia

    en.wikipedia.org/wiki/Lubani_Al_Saleh_Teebi_syndrome

    Lubani Al Saleh Teebi syndrome also known as cystic fibrosis-gastritis-megaloblastic anemia syndrome is a very rare autosomal recessive genetic disorder which consists of cystic fibrosis, helicobacter pylori-associated gastritis, folate-deficiency megaloblastic anemia and intellectual disabilities.

  7. Hypersegmented neutrophil - Wikipedia

    en.wikipedia.org/wiki/Hypersegmented_neutrophil

    The presence of hypersegmented neutrophils is an important diagnostic feature of megaloblastic anaemias. Hypersegmentation can also be seen in many other conditions but with relatively less diagnostic significance. Hypersegmentation can sometimes be difficult to assert since interobserver variation is high and segmentation may vary with race.

  8. Thomas Addison - Wikipedia

    en.wikipedia.org/wiki/Thomas_Addison

    Pernicious anemia as described in 1849 by Addison is now also known as Addison-Biermer disease. It is a type of megaloblastic anemia, in which a lack of intrinsic factor causes absorption of vitamin B 12 to be impaired. It is caused by a lack of parietal cells in the stomach. [13]

  9. Hematologic disease - Wikipedia

    en.wikipedia.org/wiki/Hematologic_disease

    Immune mediated hemolytic anemia (direct Coombs test is positive) Autoimmune hemolytic anemia. Warm antibody autoimmune hemolytic anemia. Idiopathic; Systemic lupus erythematosus (SLE) Evans syndrome (antiplatelet antibodies and hemolytic antibodies) Cold autoimmune hemolytic anemia Cold agglutinin disease; Paroxysmal cold hemoglobinuria (rare)