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It is similar to DNA but with the replacement of thymine by uracil and the adding of one oxygen atom. [1] Despite the structural similarities, much less is known about dsRNA. [2] They form the genetic material of some viruses (double-stranded RNA viruses). dsRNA, such as viral RNA or siRNA, can trigger RNA interference in eukaryotes, as well as ...
Nucleic acid (DNA and RNA) strands with corresponding sequences stick together in pairwise chains, zipping up like Velcro tumbled in a clothes dryer. But each node of the chain is not very sticky, so the double-stranded chain is continuously coming partway unzipped and re-zipping itself under the influence of ambient vibrations (referred to as thermal noise or Brownian motion).
Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories.
Double-stranded RNA viruses (dsRNA viruses) are a polyphyletic group of viruses that have double-stranded genomes made of ribonucleic acid.The double-stranded genome is used as a template by the viral RNA-dependent RNA polymerase (RdRp) to transcribe a positive-strand RNA functioning as messenger RNA (mRNA) for the host cell's ribosomes, which translate it into viral proteins.
Unlike double-stranded DNA, RNA is usually a single-stranded molecule (ssRNA) [4] in many of its biological roles and consists of much shorter chains of nucleotides. [5] However, double-stranded RNA (dsRNA) can form and (moreover) a single RNA molecule can, by complementary base pairing, form intrastrand double helixes, as in tRNA.
The 60kDa DNA/RNA binding protein and 52kDa T-cell ... Anti-double stranded DNA ... ANA can have a positive test result in up to 45% of people with ...
In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid or ribonucleic acid molecules anneal to complementary DNA or RNA. [1] Though a double-stranded DNA sequence is generally stable under physiological conditions, changing these conditions in the laboratory (generally by raising ...
Viruses containing positive-strand RNA or double-strand RNA, except retroviruses and Birnaviridae. All positive-strand RNA eukaryotic viruses with no DNA stage, such as Coronaviridae; All RNA-containing bacteriophages; the two families of RNA-containing bacteriophages are Fiersviridae (positive ssRNA phages) and Cystoviridae (dsRNA phages)