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Sometimes, hair loss is a side effect of your medication. Seeking medical help is your first port-of-call. Autoimmune hair loss can often be treated, depending on the cause.
An example of epistasis is the interaction between hair colour and baldness. A gene for total baldness would be epistatic to one for blond hair or red hair. The hair-colour genes are hypostatic to the baldness gene. The baldness phenotype supersedes genes for hair colour, and so the effects are non-additive.
This is greater than would be expected if pattern balding were a purely autosomal trait, and may suggest that there is an important paternal route of inheritance, either through a Y-chromosome gene or a paternal imprinting effect. [30] Androgens can interact with the Wnt signalling pathway to cause hair loss
The cause of male-pattern hair loss is a combination of genetics and male hormones; the cause of female pattern hair loss is unclear; the cause of alopecia areata is autoimmune; and the cause of telogen effluvium is typically a physically or psychologically stressful event. [4] Telogen effluvium is very common following pregnancy. [4]
However, one uncommon Nizoral shampoo side effect includes alopecia (hair loss). If you notice worsening hair loss when using over-the-counter ketoconazole shampoo, stop using it and switch to ...
Bile acids cause DNA damage, including oxidative DNA damage, double-strand DNA breaks, aneuploidy and chromosome breakage. [55] High-normal levels of the bile acid deoxycholic acid cause apoptosis in human colon cells, [56] but may also lead to colon cancer if repair and apoptotic defenses are insufficient. [57]
"There are many causes of hair loss, but by far the most common cause is hereditary hair loss with age," Phipps says. "Some men and women have a genetic predisposition for the hair follicles to be ...
Non-additive effects involve dominance or epistasis, and cause outcomes that are not a sum of the contribution of the genes involved. Additive genetic effects are singularly important with regard to quantitative traits , as the sum of these effects informs the placement of a trait on the spectrum of possible outcomes.